Table 3.
Laboratory and In Vitro Studies of the Patients
Patient | Delay between the onset and laboratory assessment (d) | Abnormal laboratory studies | IF sciatic nerve IgG staining |
DRG culture IgG staining | DRG section IgG staining | Interpretation of immunostaining reactivity |
1 | 22 | N | Schwann cells | — | — | Myelin |
2 | 888 | N | — | + | — | DRG |
3 | 485 | N | — | — | + | DRG (probably) |
4 | 1,213 | N | — | — | — | Negative |
5 | 3,613 | Anti-FGFR3 + | Unmyelinated fibers | + | + | Small fibers |
6 | 1,370 | B12 deficiency | Schwann cells at paranodes | — | + | Paranodes |
7 | 282 | Anti-FGFR3 + | Schwann cells | — | — | Myelin |
8 | 228 | Folate deficiency | — | + | + | DRG |
9 | 1877 | Anti-FGFR3 + | Unmyelinated fibers | — | — | Small fibers |
10 | 308 | Anti-CASPR2 + | Juxtaparanodes and unmyelinated fibers | + | + | Juxtaparanodes and small fibers |
11 | 1,572 | N | Paranodes | — | — | Paranodes |
12 | 74 | N | — | + | — | DRG |
13 | 995 | Iron-deficiency anemia | Unmyelinated fibers and paranodes | — | — | Paranodes and small fibers |
14 | 34 | Anti-Tg + | — | + | — | DRG |
15 | 170 | N | Unmyelinated fibers | + | — | Small fiber |
16 | 54 | Anti-TPO and anti-Tg + | — | — | — | Negative |
17 | 26 | N | — | — | — | Negative |
18 | 962 | Thrombocytopenia | — | — | — | Negative |
19 | 1,529 | High B6 level | — | — | — | Negative |
20 | 354 | Anti-FGFR3 + | — | — | — | Negative |
Abbreviations: + = staining; CASPR2 = contactin-associated protein-2; DRG = dorsal root ganglion; FGFR3 = fibroblast growth factor receptor 3; IF = immunofluorescence; N = normal; TG = thyroglobulin; TPO = thyroperoxidase.