Table 2.
Blood pressure and conventional echocardiographic parameters between two groups and study phase.
| Intensive treatment (N = 66) | Standard treatment (N = 50) | p Value | ||||
|---|---|---|---|---|---|---|
| Phase 1 | Phase 2 | Phase 1 | Phase 2 | Treatment | Time | |
| Blood pressure | ||||||
| SBP (mmHg) | 126.5 ± 9.0 | 125.0 ± 7.7 | 132.1 ± 9.2 | 135.3 ± 7.3 | .017† , ‡ , § | |
| DBP (mmHg) | 75.2 ± 5.6 | 76.3 ± 7.2 | 77.5 ± 7.7 | 78.7 ± 8.2 | .039 | .129 |
| Conventional echocardiographic parameters | ||||||
| LAD (cm) | 3.43 ± 0.41 | 3.35 ± 0.39 | 3.32 ± 0.38 | 3.22 ± 0.38 | .006§ | |
| IVSd (cm) | 0.99 ± 0.13 | 0.98 ± 0.13 | 0.98 ± 0.11 | 0.95 ± 0.11 | .282 | .066 |
| PWTd (cm) | 0.94 ± 0.14 | 0.97 ± 0.13 | 0.90 ± 0.11 | 0.95 ± 0.11 | .152 | .001 |
| LVEDV (mL) | 106.68 ± 22.99 | 99.68 ± 22.86 | 93.66 ± 17.58 | 91.30 ± 21.51 | .005 | .004 |
| LVESV (mL) | 33.17 ± 8.96 | 32.91 ± 11.27 | 28.92 ± 6.46 | 29.10 ± 11.27 | .011 | .968 |
| LVEF (%) | 68.98 ± 3.87 | 67.76 ± 4.89 | 68.84 ± 3.63 | 67.62 ± 5.77 | .827 | .035 |
| E/A ratio | 0.77 ± 0.17 | 0.72 ± 0.18 | 0.81 ± 0.20 | 0.76 ± 0.22 | .208 | .008 |
| LAVI (mL/m2) | 33.07 ± 8.79 | 26.58 ± 6.68 | 30.74 ± 7.38 | 27.07 ± 6.84 | .585 | <.001 |
| Mean e′ (cm/s) | 7.18 ± 1.49 | 7.08 ± 1.88 | 7.48 ± 1.52 | 7.16 ± 1.87 | .504 | .173 |
| Mean E/e′ | 10.64 ± 3.19 | 9.50 ± 2.91 | 10.49 ± 2.56 | 10.00 ± 3.19 | .709 | .003 |
| LVMI (g/m2) | 93.30 ± 25.95 | 94.50 ± 25.55 | 101.62 ± 24.69 | 99.26 ± 24.40 | .141 | .737 |
| RWT | 0.40 ± 0.01 | 0.43 ± 0.01 | 0.40 ± 0.01 | 0.43 ± 0.01 | .476 | <.001 |
Note: If no interaction between phase and treatment group exists, then data were analyzed together, with the p values as shown in the final two columns. If a phase × treatment interaction exists (i.e., effects differ over time between the two groups), this p value is shown across both final columns, then data were analyzed separately by phase and treatment. p < .05 phase 1 versus phase 2 intensive.
Abbreviations: A, A wave; DBP, diastolic blood pressure; E, E wave; e′, early diastolic velocity; IVSd, interventricular septal thickness in diastole; LAD, left atrial diameter; LAV, left atrial volume; LVEDD, left ventricular end‐diastolic dimension; LVEDV, left ventricular end diastolic volume; LVEF, left ventricular ejection fraction; LVESD, left ventricular end‐systolic dimension; LVESV, left ventricular end systolic volume; LVM, left ventricular mass; LVMI, left ventricular mass index, RWT, relative wall thickness; PWTd, posterior wall thickness in diastole; SBP, systolic blood pressure.
p < .05 intensive versus standard phase 1.
p < .05 intensive versus standard phase 2.
p < .05 phase 1 versus phase 2 standard.