1.17. Analysis.
Comparison 1 Convection (haemofiltration/haemodiafiltration/acetate‐free biofiltration) versus haemodialysis, Outcome 17 Data from cross‐over studies.
| Data from cross‐over studies | |||
|---|---|---|---|
| Study | Convective therapy | Diffusive therapy | P value from paper |
| Hospitalisation | |||
| Verzetti 1998 | 8 | 17 | Not reported |
| Patients experiencing hypotension | |||
| Fox 1993 | 1/9 | 0/9 | Not reported |
| Karamperis 2005 | 0/12 | 0/12 | Not significant |
| Pedrini 2011a | 2/62 | 5/62 | Not reported |
| Teo 1987 | 0/10 | 0/10 | Not reported |
| Intradialytic hypotensive events | |||
| Selby 2006a | 23 | 37 | Not significant |
| Stefansson 2012 | 32 dialysis sessions with hypotension from a total of 520 sessions | 28 dialysis sessions with hypotension from a total of 520 sessions | Not significant |
| Symptomatic intradialytic hypotensive events | |||
| Selby 2006a | 2 | 2 | Not significant |
| Predialysis systolic blood pressure (mm Hg) | |||
| Karamperis 2005 | 12 patients Mean (± SE): 145.0 (7) | 12 patients Mean (± SE): 144.0 (6) | Not significant |
| Noris 1998 | 5 patients Mean (± SE): 136.3 (2.7) | 5 patients Mean (± SE): 128.3 (3.6) | P > 0.05 |
| Pedrini 2011a | 62 patients Mean (± SE): 140 (22) | 62 patients Mean (± SE): 147 (22) | P = 0.014 |
| Stefansson 2012 | 20 patients Mean (± SE): 161.2 (29.9) | 20 patients Mean (± SE): 157.5 (26.1) | Not reported |
| Todeschini 2002 | 9 patients Mean (± SE): 153 (8) | 9 patients Mean (± SE): 153 (6) | P > 0.05 |
| Predialysis diastolic blood pressure (mm Hg) | |||
| Karamperis 2005 | 12 patients Mean (± SE): 81.0 (3) | 12 patients Mean (± SE): 83.0 (3) | Not significant |
| Noris 1998 | 5 patients Mean (± SE): 78.0 (2.7) | 5 patients Mean (± SE): 75.3 (3.4) | P > 0.05 |
| Pedrini 2011a | 62 patients Mean (± SE): 75.0 (13) | 62 patients Mean (± SE): 80.0 (13) | P = 0.05 |
| Stefansson 2012 | 20 patients Mean (± SE): 88.9 (12.6) | 20 patients Mean (± SE): 86.4 (10.8) | Not reported |
| Todeschini 2002 | 9 patients Mean (± SE): 83 (2) | 9 Mean (± SE): 88 (2) | P > 0.05 |
| Predialysis mean arterial pressure (mm Hg) | |||
| Karamperis 2005 | 12 patients Mean (± SE): 103.0 (4) | 12 patients Mean (± SE): 104.0 (4) | Not significant |
| Teo 1987 | 10 patients Mean (± SEM): 94.4 (6.7) | 10 patients Mean (± SEM): 94.7 (6.1) | "Statistically insignificant" |
| Postdialysis systolic blood pressure (mm Hg) | |||
| Karamperis 2005 | 12 patients Mean (± SE): 128.0 (8) | 12 patients Mean (± SE): 129.0 (5) | Not significant |
| Noris 1998 | 5 patients Mean (± SE): 136.3 (4.2) | 5 patients Mean (± SE): 127.1 (3.6) | P > 0.05 |
| Pedrini 2011a | 62 patients Mean (± SE): 138 (25) | 62 patients Mean (± SE): 138 (21) | "not differ significantly" |
| Stefansson 2012 | 20 patients Mean (± SE): 161.6 (25.1) | 20 patients Mean (± SE): 157.1 (22.8) | Not reported |
| Todeschini 2002 | 9 patients Mean (± SE): 114 (4) | 9 patients Mean (± SE): 121 (3) | P > 0.05 |
| Postdialysis diastolic blood pressure (mm Hg) | |||
| Karamperis 2005 | 12 patients Mean (± SE): 73.0 (4) | 12 patients Mean (± SE): 77.0 (4) | Not significant |
| Pedrini 2011a | 62 patients Mean (± SE): 77.0 (14) | 62 patients Mean (± SE): 76.0 (13) | "not differ significantly" |
| Stefansson 2012 | 20 patients Mean (± SE): 86.8 (12.8) | 20 patients Mean (± SE): 85.3 (10.3) | Not reported |
| Postdialysis fall in systolic blood pressure (mm Hg) | |||
| Todeschini 2002 | 9 patients Mean (± SE): ‐39 (8) | 9 patients Mean (± SE): ‐32 (6) | P > 0.05 |
| Postdialysis mean arterial pressure (mm Hg) | |||
| Karamperis 2005 | 12 patients Mean (± SE): 91.0 (5) | 12 patients Mean (± SE): 94.0 (3) | Not significant |
| Teo 1987 | 10 patients Mean (± SEM): 90.7 (3.8) | 10 patients Mean (± SEM): 96.3 (5.9) | "Statistically insignificant" |
| Difference between pre‐ and postdialysis systolic blood pressure (mm Hg) | |||
| Noris 1998 | 5 patients Mean (± SE): 0 (4.8) | 5 patients Mean (± SE): ‐0.3 (4.6) | P > 0.05 |
| Difference between pre‐ and postdialysis diastolic blood pressure (mm Hg) | |||
| Noris 1998 | 5 patients Mean (± SE): ‐1.4 (2.7) | 5 patients Mean (± SE): ‐3.1 (2.8) | P > 0.05 |
| Todeschini 2002 | 9 patients Mean (± SE): ‐8 (6) | 9 patients Mean (± SE): ‐13 (3) | P > 0.05 |
| Intradialysis mean systolic blood pressure (mm Hg) | |||
| Selby 2006a | 12 patients Mean (± SEM): 137.8 (5.3) | 12 patients Mean (± SEM): 145.5 (8.0) | P < 0.0001 |
| Intradialysis mean diastolic blood pressure (mm Hg) | |||
| Selby 2006a | 12 patients Mean (± SEM): 79.2 (1.9) | 12 patients Mean (± SEM): 80.8 (3.5) | P = 0.005 |
| Intradialysis mean arterial pressure (mm Hg) | |||
| Selby 2006a | 12 patients Mean (± SEM): 104.1(5.2) | 12 patients Mean (± SEM): 100.5 (2.9) | P < 0.0001 |
| Teo 1987 | 10 patients Mean (± SEM): 89.5 (5.6) | 10 patients Mean (± SEM): 95.3 (5.5) | "statistically insignificant decrease" |
| Kt/V | |||
| Basile 2001 | 10 patients Mean (± SD): .28 (0.05) | 10 patients Mean (± SD): 1.30 (0.05) | No significant difference |
| Kantartzi 2013 | 48 patients Mean (± SD): 1.45 (0.16) | 48 patients Mean (± SD): 1.42 (0.02) | P = 0.33 |
| Karamperis 2005 | 12 patients Mean (± SD): 1.8 (0.20) | 12 patients Mean (± SD): 1.70 (0.00) | No significant difference |
| Noris 1998 | 5 patients Mean (± SE) = 1.28 (0.08) | 5 patients Mean (± SE): 1.16 (0.11) | P > 0.05 |
| Pedrini 2011a | 62 patients Mean (± SE): 1.60 (0.31) |
62 patients Mean (± SE): 1.44 (0.26) |
P < 0.0001 |
| Righetti 2010 | 24 patients Mean (± SE): 1.6 (0.02) | 24 patients Mean (± SE): 1.51 (0.02) | P < 0.01 |
| Selby 2006a | 12 patients Mean (± SE): 1.37 (0.28) |
12 patients Mean (± SE): 1.38 (0.32) |
P = 0.91 |
| Stefansson 2012 | 20 patients Mean (± SE): 1.51 (0.2) | 20 patients Mean (± SE): 1.47 (0.24) | Not reported |
| Todeschini 2002 | 9 patients Mean (± SE): 1.54 (0.09) | 9 patients Mean (± SE): 1.46 (0.05) | P > 0.05 |
| Tuccillo 2002 | 12 patients Mean (± SD): 1.49 (0.20) | 12 patients Mean (± SD): 1.41 (0.24) | P > 0.05 |
| Urea reduction ratio | |||
| Righetti 2010 | 24 patients Mean (± SE): 73.1 (0.5) | 24 patients Mean (± SE): 70.9 (0.5) | P < 0.01 |
| Predialysis serum B2 microglobulin level (mg/L) | |||
| Kantartzi 2013 | 48 patients Mean (± SE): 31.9 (7.64) | 48 patients Mean (± SE): 47.36 (12.21) | P < 0.01 |
| Pedrini 2011a | 62 patients Mean (± SE): 22.2 (7.8) | 62 patients Mean (± SE): 33.5 (11.8) | P < 0.0001 |
| Righetti 2010 | 24 patients Mean (± SE): 26.0 (0.5) | 24 patients Mean (± SE): 30.9 (0.6) | P < 0.01 |
| Stefansson 2012 | 20 patients Mean (± SE): 23.7 (8.1) | 20 patients Mean (± SE): 34.6 (17) | Not reported |