for the main comparison.
| Convective compared with diffusive dialysis modalities for men and women with end‐stage kidney disease | ||||||
|
Patient or population: men and women with end‐stage kidney disease Intervention: convective dialysis Comparison: diffusive dialysis | ||||||
| Outcomes | Illustrative comparative risks* (95% CI) | Relative effect (95% CI) | No of participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Assumed risk | Corresponding risk | |||||
| Diffusion | Convection | |||||
| All‐cause mortality | 200 per 1000 | Not significant | RR 0.87 (0.72 to 1.05) |
11 (3396) | ⊕⊕⊝⊝ low | Convective therapy has little or no effect on all‐cause mortality |
| Cardiovascular mortality | 100 per 1000 | 75 per 1000 | RR 0.75 (0.81 to 0.92) |
6 (2889) | ⊕⊕⊝⊝ low | Convective therapy may reduce cardiovascular mortality |
| Nonfatal cardiovascular events | 130 per 1000 | Not significant | RR 1.23 (0.93‐1.63) | 2 (1688) | ⊕⊝⊝⊝ very low | Convective therapy has uncertain effects on non‐fatal cardiovascular events |
| Health‐related quality of life | Not estimable | Not estimable | Not estimable | 8 (988) | ⊕⊕⊝⊝ very low | Convective therapy has uncertain effects on health‐related quality of life |
| *The assumed risk (e.g. the median control group risk across studies) is derived from data within dialysis registries for all‐cause mortality and cardiovascular mortality and the reported event rate in the available study for nonfatal cardiovascular events (CONTRAST (Dutch) Study 2005). The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk Ratio | ||||||
| GRADE (Grading of Recommendations Assessment, Development, and Evaluation) Working Group grades of evidence (Guyatt 2011). Low quality: Indicates that our confidence in the effect estimate is limited: The true effect may be substantially difference from the estimated effect. Very low quality: Indicated that we have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimated effect. | ||||||