Comparison 1. Convection (haemofiltration/haemodiafiltration/acetate‐free biofiltration) versus haemodialysis.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	11	3396	Risk Ratio (IV, Random, 95% CI)	0.87 [0.72, 1.05]
2 Cardiovascular mortality	6	2889	Risk Ratio (IV, Random, 95% CI)	0.75 [0.61, 0.92]
3 Nonfatal cardiovascular event (rate/person‐years follow‐up)	1		Risk Ratio (IV, Random, 95% CI)	Totals not selected
4 Hospitalisation	2		Mean Difference (IV, Random, 95% CI)	Subtotals only
4.1 Hospital admissions/year	1	45	Mean Difference (IV, Random, 95% CI)	0.20 [‐0.07, 0.47]
4.2 Days spent in hospital	2	67	Mean Difference (IV, Random, 95% CI)	‐1.22 [‐7.47, 5.03]
5 Hospitalisation (rate/person‐years follow‐up)	2	400	Risk Ratio (IV, Random, 95% CI)	1.23 [0.93, 1.63]
6 Change of dialysis modality	5	2919	Risk Ratio (IV, Random, 95% CI)	0.87 [0.41, 1.84]
7 Hypotension during dialysis (rate/person‐years follow‐up)			Other data	No numeric data
8 Dialysis sessions with hypotension	2	42	Mean Difference (IV, Random, 95% CI)	‐4.05 [‐15.39, 7.30]
9 Predialysis blood pressure	7		Mean Difference (IV, Random, 95% CI)	Subtotals only
9.1 Systolic blood pressure	7	1859	Mean Difference (IV, Random, 95% CI)	1.19 [‐1.46, 3.84]
9.2 Diastolic blood pressure	6	1154	Mean Difference (IV, Random, 95% CI)	‐0.25 [‐1.06, 0.56]
10 Maximal drop in blood pressure during dialysis	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
10.1 Systolic blood pressure	1		Mean Difference (IV, Random, 95% CI)	0.0 [0.0, 0.0]
11 Kidney diseases questionnaire and well‐being scores	3		Mean Difference (IV, Random, 95% CI)	Subtotals only
11.1 Inter‐dialysis patient well‐being score	1	67	Mean Difference (IV, Random, 95% CI)	0.60 [0.30, 0.90]
11.2 Physical symptoms	2	121	Mean Difference (IV, Random, 95% CI)	‐0.54 [‐1.52, 0.44]
11.3 Fatigue	1	45	Mean Difference (IV, Random, 95% CI)	0.0 [‐0.98, 0.98]
11.4 Depression	1	45	Mean Difference (IV, Random, 95% CI)	0.20 [‐0.50, 0.90]
11.5 Relationships	1	45	Mean Difference (IV, Random, 95% CI)	0.10 [‐0.73, 0.93]
11.6 Frustration	1	45	Mean Difference (IV, Random, 95% CI)	‐0.20 [‐1.61, 1.21]
12 Kt/V	14	2022	Mean Difference (IV, Random, 95% CI)	0.07 [‐0.00, 0.14]
13 Urea reduction ratio	3	879	Std. Mean Difference (IV, Random, 95% CI)	0.39 [0.06, 0.72]
14 Predialysis serum B2 microglobulin	12	1813	Mean Difference (IV, Random, 95% CI)	‐5.55 [‐9.11, ‐1.98]
15 B2 microglobulin clearance	3	65	Mean Difference (IV, Random, 95% CI)	13.05 [‐5.94, 32.04]
16 Dialysate B2 microglobulin level	1		Mean Difference (IV, Random, 95% CI)	Totals not selected
17 Data from cross‐over studies			Other data	No numeric data
17.1 Hospitalisation			Other data	No numeric data
17.2 Patients experiencing hypotension			Other data	No numeric data
17.3 Intradialytic hypotensive events			Other data	No numeric data
17.4 Symptomatic intradialytic hypotensive events			Other data	No numeric data
17.5 Predialysis systolic blood pressure (mm Hg)			Other data	No numeric data
17.6 Predialysis diastolic blood pressure (mm Hg)			Other data	No numeric data
17.7 Predialysis mean arterial pressure (mm Hg)			Other data	No numeric data
17.8 Postdialysis systolic blood pressure (mm Hg)			Other data	No numeric data
17.9 Postdialysis diastolic blood pressure (mm Hg)			Other data	No numeric data
17.10 Postdialysis fall in systolic blood pressure (mm Hg)			Other data	No numeric data
17.11 Postdialysis mean arterial pressure (mm Hg)			Other data	No numeric data
17.12 Difference between pre‐ and postdialysis systolic blood pressure (mm Hg)			Other data	No numeric data
17.13 Difference between pre‐ and postdialysis diastolic blood pressure (mm Hg)			Other data	No numeric data
17.14 Intradialysis mean systolic blood pressure (mm Hg)			Other data	No numeric data
17.15 Intradialysis mean diastolic blood pressure (mm Hg)			Other data	No numeric data
17.16 Intradialysis mean arterial pressure (mm Hg)			Other data	No numeric data
17.17 Kt/V			Other data	No numeric data
17.18 Urea reduction ratio			Other data	No numeric data
17.19 Predialysis serum B2 microglobulin level (mg/L)			Other data	No numeric data