Kantartzi 2013.

Methods	Study design: cross‐over RCT Study time frame: not stated Duration of follow‐up: 3 months on each dialysis technique
Participants	Country: Greece Setting: single centre Age > 18 years, regular (for at least 3 months) HD 3 times/week Mean time on dialysis: 31 ± 23.28 months Number: 24 Mean age ± SD: 62 ± 13.34 years Sex (M/F): 19/5 Exclusion criteria: not stated
Interventions	Treatment group 1 On‐line high‐flux HDF Treatment group 2 High‐flux HDF with prepared bags of substitution (HDF) Control group Low‐flux conventional HD
Outcomes	QoL Kt/V B2 microglobulin
Notes	Exclusions post randomisation but pre‐intervention: not stated Stop or end point/s: not stated Funding: not stated, "The authors report no conflicts of interest."
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not stated
Allocation concealment (selection bias)	Unclear risk	Not stated
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not stated
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not stated
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Lost to follow‐up 2/24; no clear description of drop‐outs or reasons
Selective reporting (reporting bias)	High risk	Data at the end of first phase of treatment not available
Other bias	High risk	Carry over effect due to cross‐over design, interventions not matched