. 2023 Oct 31;147(1):177–185. doi: 10.1093/brain/awad374

Table 1.

Serostatus of HHV-6A and sNfL in cases and controls

	Cases			Controls		P
HHV-6A+ (n, %)	208/519, 40%			132/519, 25%		<0.001^a
sNfL (geometric mean, pg/ml)	7.07 (6.70–7.45)			6.21 (5.93–6.50)		<0.001^b
	HHV-6A+	HHV-6A−	P	HHV-6A+	HHV-6A−	P
sNfL (geometric mean, pg/ml)	7.65 (6.99–8.37)	6.70 (6.28–7.15)	0.02^c	6.35 (5.82–6.93)	6.16 (5.84–6.50)	0.57^c
sNfL ratio (geometric mean)	1.21 (1.09–1.34)	1.09 (1.02–1.17)	0.11^c	0.88 (0.78–1.00)	0.88 (0.82–0.94)	0.92^c
Age-adjusted sNfL z-score (mean)	1.12 (0.96–1.28)	0.92 (0.79–1.06)	0.07^c	0.76 (0.55–0.98)	0.73 (0.61–0.85)	0.79^c

Mean values with 95% confidence intervals. The sNfL ratio was calculated for each matched case-control set. Age-adjusted sNfL z-scores were calculated with sNfL reference application. HHV-6A seropositivity was defined as a seroresponse >50 MFI against HHV-6A antigen IE1A. HHV-6A = human herpesvirus 6A; MFI = median fluorescence intensity; sNfL = serum neurofilament light chain.

^aMcNemar test.

^bPaired samples t-test.

^cIndependent samples t-test.