Figure 1.

Effects of pasteurized A. muciniphila on colonic hypersensitivity induced in a non-inflammatory IBS mouse model. The sNMS mice that underwent a neonatal maternal separation paradigm and developed a colonic hypersensitivity, were treated for 10 days by gavage with a vehicle (sNms/veh) or with two different doses (3×10⁹ TFU for the sNMS/1 group or 6 × 10⁸ TFU for the sNMS/5 group) of pasteurized A. muciniphila (pAkk) (n = 10 males and n = 10 females per group). (a) Intracolonic pressure variation in response to a colorectal distension in male sNMS mice. (b) Intracolonic pressure variation in response to a colorectal distension in female sNMS mice. (c) Total area under the curve (AUC) for both male and female sNMS mice. Data are from two independent experiments. *p < 0,05; **p < 0.01; ***p < 0.001 sNms/veh vs. sNMS/1.