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. 2024 Jan 3;16(1):2298026. doi: 10.1080/19490976.2023.2298026

Figure 4.

Figure 4.

Effects of pasteurized A. muciniphila on intestinal tight junction protein expression in a post-infectious IBS mouse model. Mice were infected with citrobacter rodentium to induce a PI-IBS mouse model. The non-infected mice were inoculated with 200 µL of sterile PBS. During the post-infectious phase, mice were treated by gavage for 8 days from 16 days post infection (DPI) to 23 DPI. Non-infected (Ni/veh) and infected (Citro/Veh) mice were forced-fed with the vehicle. Non-infected mice from the NI/1 group were forced-fed with the highest dose (3×109 TFU) of pasteurized A. muciniphila (pAkk). Mice from the Citro/1 and Citro/5 group were forced-fed with the highest dose (3×109 TFU) or the lowest dose (6×108 TFU) of pasteurized A. muciniphila. Colonic expression of (a) ZO-1, (b) Occludin and (c) claudin-2 mRNA in each mouse group (n = 9–20 per group) was quantified by RT-qPCR. Data are from two independent experiments. *p < 0.05; **p < 0.01; ****p < 0.0001.