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. 2023 Dec 27;53(1):18–22. doi: 10.1038/s41684-023-01307-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a, Schematic illustration of the multi-laboratory study design. b,c, The phenotype of mice was shaped by both breeding site (b) and test laboratory (c). In the LDA plots, color indicates breeder (b) and test laboratory (c). Filled dots represent a correct classification based on LDA, empty dots represent mismatches. d, Ratio of standard deviations of HET over STA cohorts for each outcome variable and each laboratory. A ratio >1 indicates that variation was larger in the HET compared to the STA cohort. BS, breeding site; LAB, test laboratory; LD, linear discriminant.