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. 2022 Dec 30;3(2):164–173. doi: 10.1038/s43588-022-00375-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, Positions of the hypothetical highest-potency antibodies with the smallest IC₅₀ against all H1N1 (green) or H3N2 (blue) vaccine strains from the 2004–2005 to 2018–2019 seasons, compared to the best antibody in the panel (gray, labeled below with their names). A circle corresponding to the minimal IC₅₀ enclosing all relevant viruses is drawn around each antibody. b, Predicting the highest-potency antibody (purple) that neutralizes both the H1N1 and H3N2 strains compared to the best antibody in our panel (gray).

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