Fig. 3. Differential adverse events across gender and age.
a,b, PAEAI differences across gender (a) and age (b). A higher PAEAI value indicates a more substantial deviation of an adverse event’s incidence from historical trends than expected by simulation. c, Gender differences in the reporting of adverse events. Highlighted in bold are five adverse events with the largest differential increase. The first number indicates the absolute difference in the number of reports, and the number in parentheses is normalized by population size (Supplementary Fig. 4). A negative number implies smaller frequency in women than in men. Standard deviations of PAEAIs are calculated via bootstrapping with replacement on patient safety data. GI hemorrhage, gastrointestinal hemorrhage; GPHD, general physical health deterioration; PAH: pulmonary arterial hypertension; HGG, hypogammaglobulinemia; NMS, neuroleptic malignant syndrome.