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. 2022 Feb 24;2(2):84–89. doi: 10.1038/s43588-022-00199-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — A Illustration of the method for generating layouts that combine structural and functional features in a tunable fashion. The structural aspect of the layout is derived from the global layout, where each node in the network is represented by a feature vector containing random walk visiting frequencies to all other nodes. The functional aspect is then introduced by adding an additional column for each functional feature to be included in the layout, for example associations with different diseases. These functional columns contain values ‘1’ or ‘0’, depending on whether a particular node is associated with the respective feature (value ‘1’) or not (value ‘0’). Scaling the functional columns by a factor m ≥ 0 allows to modulate between purely structural layouts (m = 0) and layouts that are increasingly dominated by the functional annotations (m > 0). B Application of the method to a simple model network with ring structure three node annotations, indicated by different colors. As the modulation factor increases from m = 0 to m = 10, the layout transitions from a purely structural one, to one dominated by the node annotations alone.