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. 2024 Jan 4;14(1):1. doi: 10.1038/s41408-023-00969-6

Fig. 1. The inactivation of Trp53 does not modify the JAK2V617F-induced MPN phenotype.

Fig. 1

A–C Data of cell count of peripheral blood (PB) from C57Bl/6, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre/Trp53−/− mice, graph represents pooled mice from three independent experiment, each with 3-4 mice per group. (A: white blood cell, B: hematocrit, C: platelet). D The spleen of C57Bl/6, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53−/− mice. The graph represents from three independent experiments, each with 3-4 mice per group. E The spleen weight from C57Bl/6, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53−/− mice at 1 to 3 months old. Graph represents pooled mice from three independent experiment, each with 3-4 mice per genotype. F Percent survival of JAK2V617F/Vav-Cre and JAK2V617F/Vav-Cre /Trp53−/− mice. G Histopathologic characterization of the bone marrow (BM). The first column is the BM of C57Bl/6 mice, the second column is the BM from 1-month-old JAK2V617F/Vav-Cre mice, the third column is BM from 3-month-old JAK2V617F mice, the fourth column is BM from 1-month-old JAK2V617F/Trp53−/− mice, and the fifth column is BM from 3-month-old JAK2V617F/Trp53−/− mice. The first row to third row respectively the 100×, 200×, and 400× objectives. The samples on the fourth row were silver stained, and the samples on the other rows were hematoxylin and eosin stained. Images were obtained using a microscope with an Olympus camera.