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. 2024 Jan 4;14(1):1. doi: 10.1038/s41408-023-00969-6

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — A Representative flow cytometric plots of LK (Lin⁻sca⁻c-kit⁺) and LSK (Lin⁻sca⁺c-kit⁺) cell percentages from the bone marrow (BM) of C57B/l, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. B The total number of LK and LSK cells from the BM of C57B/l, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. Graph represents pooled mice from three independent experiments, each with 3-4 mice per genotype. C Representative flow cytometric plots of CMP (Lin⁺sca⁺c-kit⁺CD34⁺CD16/32), GMP (Lin⁺sca⁺c-kit⁺CD34⁺CD16/32⁺), and MEP (Lin⁺sca⁺c-kit⁺CD34⁻CD16/32⁻) cell percentages from the BM from C57B/l, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre/Trp53^−/− mice. D Total numbers of LT-HSC, ST-HSC, and MPP cells from the BM of C57B/l, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. Graph represents three independent experiments, each with 3-4 mice per genotype. E Representative flow cytometric plots of LT-HSC (Lin⁻sca⁺c-kit⁺CD150⁻CD48⁻), ST-HSC (Lin⁻sca⁺c-kit⁺CD150⁺CD48⁻), and MPP (Lin⁻sca⁺c-kit⁺CD150⁻CD48⁺) cell percentages from the BM of C57B/l, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. F Total numbers of CMP, GMP, and MEP cells from the BM of C57B/l, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. Graph represents pooled mice from three independent experiment, each with 3-4 mice per group. G The total number of LK and LSK cells from the spleen of C57B/l6, JAK2V617F, and JAK2V617F/p53^−/− mice. H The total number of CMP, GMP, and MEP cells from the spleen of C57B/l6, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. Graph represents pooled mice from three independent experiment, each with 3-4 mice per genotype. I The total number of LT-HSC, ST-HSC, and MPP cells from the spleen of C57B/l6, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. Graph represents pooled mice from three independent experiment, each with 3-4 mice per genotype. J The percentage of BrdU⁺ cells of LT-HSC, ST-HSC, and MPP from the BM of C57B/l6, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. Graph represents pooled mice from three independent experiment, each with 3-4 mice per genotype. K The percentage of BrdU⁺ cells of CMP, GMP, and MEP from the BM of C57B/l6, JAK2V617F/Vav-Cre, and JAK2V617F/Vav-Cre /Trp53^−/− mice. Graph represents pooled mice from three independent experiment, each with 3-4 mice per genotype. Data are mean ± SD *p < 0.05, **p < 0.01, ***p < 0.001.