Table 3.
League table of FPG (upper right quarter) and 2h PPG (lower left quarter).
| Placebo | −14.87 (−23.34, −6.30) | −15.87 (−21.42, −9.88) | −18.02 (−20.64, −15.13) | −20.40 (−26.07, −14.57) | −19.20 (−29.90, −8.12) | −9.97 (−32.71, 13.08) | −15.27 (−31.23, 1.03) | 16.21 (4.77, 28.36) |
| NA |
Teneligliptin
5 mg |
−0.99 (−9.87, 8.05) | −3.15 (−11.65, 5.37) | −5.53 (−14.81, 3.49) | −4.32 (−17.68, 9.34) | 4.90 (−18.41, 29.21) | −0.40 (−18.00, 17.98) | 31.08 (17.22, 45.38) |
| 45.09 (24.57, 64.93) | NA |
Teneligliptin
10 mg |
−2.16 (−7.94, 3.47) | −4.54 (−11.12, 1.87) | −3.33 (−15.23, 8.54) | 5.90 (−17.06, 29.54) | 0.60 (−16.16, 17.68) | 32.07 (19.50, 44.84) |
| 45.61 (36.29, 53.97) | NA | 0.52 (−19.81, 20.53) |
Teneligliptin
20 mg |
−2.38 (−8.15, 3.41) | −1.17 (−11.70, 9.39) | 8.06 (−14.35, 30.95) | 2.75 (−13.01, 18.89) | 34.23 (22.96, 45.93) |
| 53.00 (32.80, 73.09) | NA | 7.91 (−14.68, 30.84) | 7.39 (−12.56, 27.84) |
Teneligliptin
40 mg |
1.20 (−10.38, 13.21) | 10.43 (−12.65, 34.16) | 5.13 (−11.66, 22.21) | 36.61 (24.01, 49.33) |
| 58.79 (15.27, 104.65) | NA | 13.70 (−33.42, 62.96) | 13.18 (−29.91, 58.23) | 5.79 (−41.47, 55.43) |
Sitagliptin
100 mg |
9.23 (−16.00, 33.26) | 3.93 (−15.30, 23.23) | 35.40 (20.15, 51.02) |
| 41.41 (5.33, 76.86) | NA | −3.68 (−43.67, 35.64) | −4.20 (−38.77, 30.03) | −11.59 (−52.29, 27.73) | −17.38 (−74.25, 38.24) |
Vildagliptin
100 mg |
−5.30 (−32.85, 22.49) | 26.17 (0.15, 51.36) |
| 34.04 (−12.59, 77.95) | NA | −11.05 (−60.74, 36.33) | −11.57 (−56.89, 31.81) | −18.95 (−68.78, 28.22) | −24.75 (−88.81, 35.62) | −7.37 (−63.51, 48.31) |
Metformin
500 mg |
31.48 (12.10, 50.80) |
| −15.31 (−41.06, 9.97) | NA | −60.40 (−91.62, −28.94) | −60.92 (−84.64, −36.67) | −68.31 (−99.66, −36.79) | −74.10 (−124.95, −24.55) | −56.72 (−98.61, −14.95) | −49.35 (−97.98, 1.49) |
Bromocriptine
0.8 mg |
The relative effect sizes are measured as a mean difference along with 95% CIs. The differences between the compared groups are deemed as significant when the 95% CIs did not contain 0.00. The results with significant differences are marked with blue background, and the results without significant differences are marked with gray background. The doses of all the antidiabetic drugs are daily dose. The unit of FPG and 2h PPG is mg/dL. FPG, fasting plasma glucose; 2h PPG, 2 h postprandial plasma glucose; NA, not available.