Table 4.

Multivariate associations of primary outcomes

	Model 1 (χ2 = 7.9)			Model 2 (χ2 = 18.4)			Model 3 (χ2 = 31.5)
	HR	95% CI	P-value	HR	95% CI	P-value	HR	95% CI	P-value
Clinical parameter
Age	1.01	0.95–1.07	0.84	1.01	0.95–1.08	0.68	1.02	0.96–1.08	0.53
Gender	1.16	0.58–2.31	0.67	1.18	0.59–2.38	0.64	1.13	0.56–2.28	0.73
STS score	0.98	0.91–1.04	0.48	0.99	0.93–1.06	0.81	0.97	0.91–1.04	0.41
NYHA	1.87	1.19–2.92	0.006	1.98	1.22–3.20	0.005	2.03	1.24–3.32	0.005
Echocardiography
LVEF				1.00	0.97–1.03	0.98	1.02	0.99–1.06	0.19
LF				0.52	0.19–1.39	0.19	0.31	0.11–0.86	0.024
LG				2.73	1.43–5.23	0.002	1.81	0.89–3.68	0.103
Cluster
Cluster 3 vs. Cluster 1/2							4.18	1.76–9.94	0.001

HR, hazard ratio; CI, confidence interval; LF, low flow; LG, low gradient; other abbreviations as in Table 1.