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. 2024 Jan 4;15(1):3. doi: 10.1038/s41419-023-06389-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The circRNAs target PI3K/AKT axis to regulate cell proliferation and metastasis in the context of various cancers, such as circVRK1/miR-624-3p/PTEN, circLARP4/miR-1323/PTEN, and circ_0007624/miR-224-5p/CPEB3 pathway targeting PI3K/AKT axis in esophageal cancer; ciRS-7/miR-7/PTEN, circPVT1/miR-152-3p/HDGF, and circPIP5K1A/miR-671-5p/KRT80 pathway targeting PI3K/AKT axis in gastric cancer; circIL4R/miR-761/TRIM29/PHLPP1, circ_0008285/miR-382-5p/PTEN, and circ-0001313/miRNA-510-5p/AKT2 pathway targeting PI3K/AKT axis in colorectal cancer; circCDYL/miR-892a and miR-328-3p, circCDK13/JAK/STAT, and circEPHB4/HIF-1ɑ pathway targeting PI3K/AKT axis in liver cancer; circBFAR/miR-34b-5p/MET, circEIF6/miR-557/SLC7A11, and circNFIB1/miR-486-5p/PIK3R1/VEGF-C pathway targeting PI3K/AKT axis in pancreatic cancer; circ0014359/miR-153, circHIPK3/miR-524-5p/KIF2A, circPIP5K1A/miR-515-5p/TCF12, and circ0000215/miR-495-3p/CXCR2 pathway targeting PI3K/AKT axis in glioma.