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. 2024 Jan 4;15(1):3. doi: 10.1038/s41419-023-06389-5

Fig. 8. The circRNAs involving in Wnt/β-catenin signaling to regulate cell proliferation in the context of various cancers.

Fig. 8

In lung cancer, circ-EIF3I/miR-1253/NOVA2, circVAPA/miR-876-5p/WNT5A, circ-ZNF124/miR-498/YES1, and cir-ITCH/miR-7, miR-214/ ITCH pathway have been confirmed to affect the proliferation phenotype by targeting Wnt/β-catenin signaling. In hepatocellular carcinoma, circMTO1/miR-541-5p/ZIC1, hsa_circRNA_104348/miR-187-3p/RTKN2, circRNA-SORE/miR-103a-2-5p and miR-660-3p, circZFR/miR-3619-5p/CTNNB1 pathways have been reported to modulate cell proliferation by affecting Wnt/β-catenin signaling. In gastric cancer, circAXIN1-encoded protein AXIN1-295aa/APC, circ_SMAD4/miR-1276/TCF4/CTNNB1, cir-ITCH/miR-17/ITCH, circCNIH4/DKK2/FRZB axis have been confirmed to regulate proliferation by targeting Wnt/β-catenin signaling pathway. In colorectal cancer, circ-ACAP2/miR-143-3p/FZD4 axis, circAGFG1/miR-4262 and miR-185-5p/YY1 and CTNNB1, circ5615/miR-149-5p/TNKS, hsa_circ_0009361/miR-582/APC2 pathway were reported to influence proliferation via modulating Wnt/β-catenin signaling.