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. 2024 Jan 4;9:5. doi: 10.1038/s41541-023-00803-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a A peptide segment from MEG-4.1 (Smp_307220.2) (left panels) and a 58-mer phage-peptide from a MEG-4.1 in silico-designed splice variant (right panels) that were included in the peptide microarray are shown at the bottom of each chart; microarray adapter stretches at both ends of the sequences are highlighted with a grey background, while canonical positions have a salmon background. The upper charts represent the percentage of rhesus macaques (out of 8 animals) exhibiting antibody reactivity against epitopes from that peptide, and each line color represents a different week post-infection (wk6pi, wk8pi, wk10pi, wk42pi) or post-challenge (wk1pc and wk4pc) (legends on top of upper charts). The lower charts depict the median normalized signal intensities at each week post-infection/challenge. The colored blocks at the lowermost sequence in each panel highlight the epitopes recognized by at least 50% of rhesus macaques (out of 8 animals); some motifs that are underlined were recognized by sera from infected hamsters or infected mice, and each color denotes distinct epitopes or different species (see below). b Upper chart shows the fraction of hamsters (out of 5 animals) exhibiting week 22 post-infection (wk22pi) serum reactivity against an epitope from that peptide sequence. Lower chart represents the median normalized signal intensities. c Upper chart shows the fraction of mice (out of 7 animals) exhibiting week 6 post-infection (wk6pi) serum reactivity against an epitope from that peptide sequence. The lower chart represents the median normalized signal intensities. Images created with Biorender.com.