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. 2024 Jan 4;9:5. doi: 10.1038/s41541-023-00803-x

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — a The MEG-12 58-mer phage-peptide sequence is shown at the bottom of each chart; microarray adapter stretches at both ends are highlighted with a grey background. Note that the 16-aa N-terminal sequence of MEG-12 is duplicated at the end of the 42-aa original sequence in this phage-display peptide construct. The upper chart represents the percentage of rhesus macaques (out of 8 animals) exhibiting antibody reactivity against an epitope from that peptide, and each line color represents a different week post-infection (wk6pi, wk8pi, wk10pi, wk42pi) or post-challenge (wk1pc and wk4pc) (legends on top of upper charts). The lower chart represents the median normalized signal intensities at each week post-infection/challenge. The colored block at the lowermost sequence highlights the epitope recognized by at least 50% of rhesus macaques (out of 8 animals); part of the underlined motif is in common with the motif recognized by sera from infected mice (see below). b Upper chart shows the fraction of mice (out of 7 animals) exhibiting week 6 post-infection (wk6pi) serum reactivity against an epitope from the MEG-12 peptide sequence. The lower chart represents the median normalized signal intensities. Images created with Biorender.com.