Humaidan 2010.

Methods	Randomised, controlled, 3‐centre study
Participants	302 normo‐gonadotrophic IVF/ICSI participants, 25 to 40 years of age, BMI 18 to 30 kg/m2, basal FSH < 12 IU/L, menstrual cycle 25 to 34 days, both ovaries present, absence of uterine abnormalities. Each participant contributed with only 1 cycle Baseline characteristics: 31.5 vs 30.9 years of age, BMI 23.8 vs 23.5, basal FSH 6.7 vs 6.7
Interventions	Ovarian stimulation: adjustable dose of 150 to 200 IU rFSH + 0.25 mg ganirelix Intervention: 0.5 mg buserelin SC plus 1500 IU HCG IM 35 hours after triggering of ovulation vs 10,000 IU HCG Luteal phase support: 90 mg/d progesterone vaginal plus 4 mg/d oestradiol, beginning on the day after OPU and continuing until the day of the pregnancy test
Outcomes	Primary outcomes: reduction in high early pregnancy loss rate Secondary outcomes: MII oocytes retrieved, OHSS incidence, ongoing pregnancy rate
Notes	A total of 305 participants were included in the study, but 3 were not randomly assigned because of inadequate ovarian response Not stated whether investigators received commercial funding
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer generated
Allocation concealment (selection bias)	Unclear risk	Sealed envelopes. No further details were reported
Blinding (performance bias and detection bias) FOR OHSS OUTCOME	High risk	Participants, those administering interventions and those assessing outcomes were not blinded to group assignment. Risk applies to assessment of OHSS
Incomplete outcome data (attrition bias) All outcomes	Low risk	No outcome data were missing
Selective reporting (reporting bias)	Low risk	Study protocol is not available, but it is clear that published reports include most expected outcomes
Other bias	Low risk	No other potential bias was identified