Segal 1992.
| Methods | RCT, single‐centre study | |
| Participants | 179 women in the IVF programme | |
| Interventions | Subcutaneous injection of leuprolide acetate (500 micrograms) or intramuscular injection of HCG (5000 IU) 34 to 36 hours before oocyte retrieval. Vaginal progesterone (P) suppositories (50 mg) were used 2 times a day for luteal phase support. Subgroup of 41 women had serum oestradiol (E2) and P levels determined 2 and 7 days after embryo transfer (ET) | |
| Outcomes | Pregnancy rates and luteal phase E2 and P were compared | |
| Notes | ||
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Insufficient information: Full text was unavailable |
| Allocation concealment (selection bias) | Unclear risk | Insufficient information: Full text was unavailable |
| Blinding (performance bias and detection bias) FOR OHSS OUTCOME | Unclear risk | Insufficient information: Full text was unavailable |
| Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Insufficient information: Full text was unavailable |
| Selective reporting (reporting bias) | Unclear risk | Insufficient information: Full text was unavailable |
| Other bias | Unclear risk | Insufficient information: Full text was unavailable |
Abbreviations:
ART: assisted reproductive technology.
BMI: body mass index.
COH: controlled ovarian hyperstimulation.
CPR: clinical pregnancy rate.
ER: egg retrieval.
ET: embryo transfer.
FR: fertilisation rate.
FSH: follicle‐stimulating hormone.
GnRH: gonadotropin‐releasing hormone.
HCG: human chorionic gonadotropin.
ICSI: intracytoplasmic sperm injection.
IR: implantation rate.
ITT: intention‐to‐treat.
IVF: in vitro fertilisation.
LH: luteinising hormone.
LPS: luteal phase support
OCP: oral contraceptive pills
OHSS: ovarian hyperstimulation syndrome.
P: progesterone.
PCOM: polycystic ovary morphology
PCOS: polycystic ovary syndrome.
PP: per‐protocol.
RCT: randomised controlled trial.
rHCG: recombinant human chorionic gonadotropin.
TNFa: tumor necrosis factor‐alpha.
TPP: treatment per protocol
VEGF: vascular endothelial growth factor.