FIGURE 6.

The effect sizes of IFNL SNPs from our study for male‐specific monocyte counts and SGOT levels are better than that for many of the top genes/SNPs for the respective phenotypes represented in the GBE. The summary statistics (beta values, p‐values and MAFs) for the top genes/SNPs in terms of effect sizes (red balls) or significance (gray balls) were obtained from the GBE PheWAS database. The MAFs are represented by showing the gene/SNP IDs in different colors, as explained at the bottom of the figure. Note that the majority of the genes/SNPs that have the best effect and significance on the two phenotypes have low MAFs. The beta coefficient for the SNPs derived from our study (only from male sub‐cohort), shown as purple balls, were calculated in a multiple linear regression model after standardization with age as a covariate. GBE, global biobank engine; MAF, minor allele frequency.