Table 3.

The lncRNAs‐circRNAs in regulating the esterification of lipids and the metabolism of lipid droplets (LDs) in cancer.

Lipid metabolic lncRNAs	Status in tumor	Lipid metabolic process	Cancer types	Clinical association	Functional impact	Interactor	Target/effect	Mechanistic classification	Refs
HULC	Up‐regulated	Long‐chain fatty acids esterification	Hepatocellular carcinoma (HCC)	N.A	Proliferation↑ Lipid metabolism↑	miR‐9	Regulating HCC growth through ACSL1‐mediated lipogenesis	Epigenetic modification of miRNAs gene (Releasing miR‐9‐mediated repression of ACSL1 expression through inducing methylation of CpG islands in the promoter of miR‐9)	[ 148 ]
CircPDHX	Up‐regulated	Long‐chain fatty acids esterification	Prostate cancer (PCa)	N.A	Proliferation↑ Migration↑ Fatty acid metabolism↑	miR‐497‐5p	Promoting ACSL1‐mediated proliferation and migration	Sequestration of miRNAs (Releasing miR‐497‐5p‐mediated repression of ACSL1 expression)	[ 150 ]
SNHG7	Up‐regulated	Long‐chain fatty acids esterification	Thyroid cancer (TC)	N.A	Proliferation↑ Migration↑	miR‐449a	Promoting ACSL1‐mediated proliferation and migration	Sequestration of miRNAs (Releasing miR‐449a‐mediated repression of ACSL1 expression)	[ 151 ]
PRADX	Up‐regulated	Long‐chain fatty acids esterification	Glioblastoma (GBM)	Poor prognosis↑	Energy metabolism↑ Tumorigenesis↑	EZH2	Promoting ACSL1‐mediated basal respiration, proton leak and ATP production	Binding with protein (Binding EZH2 to recruit H3K27me3 of BLCAP promoter and further to activate the phosphorylation of STAT3 and its downstream genes’ expression, including ACSL1)	[ 149 ]
CBSLR	Up‐regulated	Long‐chain fatty acids esterification	Gastric cancer (GC)	TNM stage↑ Overall survival↓ Disease free survival↓	Ferroptosis↓ Chemoresistance↑	YTHDF2	Inhibiting ACSL4‐mediated ferroptosis under hypoxia	Binding with protein (Binding YTHDF2 to form a CBSLR/ YTHDF2/CBS signaling axis to decrease the stability of CBS mRNA, which further reduces the methylation of the ACSL4 protein, leading to protein polyubiquitination and degradation of ACSL4.)	[ 155 ]
CircLMO1	Down‐regulated	Long‐chain fatty acids esterification	Cervical cancer	FIGO staging↑	Proliferation↑ Metastasis↑	miR‐4192	Promoting ACSL4‐mediated ferroptosis	Sequestration of miRNAs (Releasing miR‐4192‐mediated repression of ACSL4 expression)	[ 153 ]
CircSCN8A	Down‐regulated	Long‐chain fatty acids esterification	Non‐small cell lung cancer (NSCLC	Aggressive clinicopathological characteristics↑ Poor prognosis↑	Proliferation↑ Migration↑ Invasion↑ EMT↑	miR‐1290	Promoting ACSL4‐mediated ferroptosis	Sequestration of miRNAs (Releasing miR‐1290‐mediated repression of ACSL4 expression)	[ 154 ]
NEAT1	Up‐regulated	Long‐chain fatty acids esterification	Prostate cancer (PCa)	N.A	Proliferation↑ Invasion↑ Docetaxel resistance↑	miR‐34a‐5p miR‐204‐5p	Regulating ACSL4‐mediated docetaxel resistance	Sequestration of miRNAs (Releasing miR‐34a‐5p and miR‐204‐5p‐mediated repression of ACSL4 expression)	[ 152 ]
CircLDLR (circ_0 0 06877)	Up‐regulated	Cholesterol esterification	Colorectal cancer (CRC)	Poor prognosis↑	Proliferation↑ Migration↑ Invasion↑ Cholesterol levels↑	miR‐30a‐3p	Promoting SOAT1‐mediated cell growth, migration, invasion and cholesterol levels increase	Sequestration of miRNAs (Releasing miR‐30a‐3p‐mediated repression of SOAT1 expression)	[ 156 ]
CircRPL23A	Down‐regulated	Cholesterol esterification	Clear cell renal cell carcinoma (ccRCC)	N.A	Proliferation↑ Migration↑ Invasion↑ Apoptosis↓	miR‐1233	Inhibiting ACAT2‐mediated suppressing cell cycle progression, proliferation, migration and invasion	Sequestration of miRNAs (Releasing miR‐1233‐mediated repression of ACAT2 expression)	[ 157 ]
Linc01410	Up‐regulated	Lipid Drops formation	Cervical cancer	Poor overall survival↑	Lipid Drop accumulation↑ Invasion↑ Migration↑	miR‐532‐5p	Increasing FASN and PLIN2 expression to facilitate the LD accumulation	Sequestration of miRNAs (Releasing miR‐532‐5p‐mediated repression of FASN expression)	[ 158 ]
SPRY4‐IT1	Up‐regulated	Lipid Drops formation	Melanoma	N.A	Lipin 2‐mediated lipid metabolism↑ Apoptosis↓	lipin2	Accumulation of lipin2 protein↓ Expression of DGAT2↓	Binding with protein (Binding lipin2 to decrease its accumulation)	[ 159 ]
NEAT1	Up‐regulated	Lipolysis	Hepatocellular carcinoma (HCC)	Tumor size↑ DAG and FFA levels↑ Overall survival↓	Proliferation↑ Lipolysis↑	miR‐124‐3p	ATGL‐mediated Lipolysis↑ FAO↑	Sequestration of miRNAs (Releasing miR‐124‐3p‐mediated repression of ATGL expression)	[ 160 ]
NEAT1	Up‐regulated	Lipolysis	Ovarian cancer	N.A	Proliferation↑ Migration↑ Invasion↑	Let‐7 g	Promoting ATGL‐mediated lipolysis and tumor progression	Sequestration of miRNAs (Releasing let‐7 g‐mediated repression of MEST expression)	[ 197 ]
Circ‐cMras	Down‐regulated	Lipolysis	Lung adenocarcinoma (LAC)	N.A	Progression↑ Tumorigenesis↑	N.A	Modulating ABHD5/ATGL axis mediated in the proliferation and aggression	Signaling pathway (Regulating ABHD5 possibly via NF‐κB signaling pathway)	[ 161 ]
CircRIC8B	Up‐regulated	Lipolysis	Chronic lymphocytic leukemia (CLL)	Advanced progression ↑ Poor prognosis↑	Proliferation↑ Lipid accumulation↑	miR‐199b‐5p	Promoting LPL ‐mediated lipid metabolism alteration and the progression	Sequestration of miRNAs (Releasing miR‐199b‐5p‐mediated repression of LPL expression)	[ 162 ]
NMRAL2P	Down‐regulated	Lipolysis	Gastric cancer (GC)	N.A	Proliferation↑ Migration↑ Invasion↑ Cell cycle progression↑ Apoptosis↓	N.A	Inhibiting ACOT7‐mediated hydrolysis of fatty acyl‐CoAs	Epigenetic modification (Down‐regulation of ACOT7 through inducing methylation of CpG islands in its promoter by interacting DNMT3b)	[ 163 ]
COL18A1‐AS1	Down‐regulated	lipid browning	Clear cell renal cell carcinoma (ccRCC)	Overall survival↓ Tumor grade and stage↑	Tumor progression↑ Lipid browning and consumption↑	miR‐1286	Increasing the expression of KLF12 to regulate UCP1‐mediated lipid browning	Sequestration of miRNAs (Releasing miR‐1286‐mediated repression of KLF12 expression)	[ 164 ]

PS: N.A. Not Available.