Fig. 7.

(a) Hemolysis of MCS NPs at various concentrations. (b) The time-dependent volume of SMMC7721/S tumor-bearing mice after systemic administration of different treatments. (SF: sorafenib) (n = 5, mean ± SD, ***P < 0.001, t-test). (c) Body weight changes of tumor-bearing mice during treatment. (n = 5, mean ± SD). (d) Photographs of five group tumor-bearing after treatment. (e) The H&E-stained tumor slices were photographed in different groups after two treatments. Scale bar: 100 μm. (f) The fluorescence images of SMMC7721/S tumor slices were collected from different groups. The nuclei and hypoxic areas were stained with DAPI (blue), and HIF-1α antibody (red), respectively. Scale bar: 100 μm. (g) The Ki67-stained tumor slices were collected from mice for different groups after two treatments. Scale bar: 100 μm. (h) Blood vessel staining (CD34) of tumor tissue after different treatments. The red arrows indicate capillaries. Scale bar: 100 μm. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)