Table 1.
Characteristics of All SF3B1MUT and BAP1MUT Tumors in the Rotterdam Ocular Melanoma Study Group Cohort
| Characteristics | SF3B1 (n = 59) | SF3B1 8q Gain (n = 48) | SF3B1 No 8q Gain (n = 11) | 3 copies 8q (n = 37) | ≥ 4 copies 8q (n = 11) | BAP1(n = 211) | BAP1 8q Gain (n = 181) | BAP1 No 8q Gain (n = 30) | 3 Copies 8q (n = 97) | ≥ 4 Copies 8q (n = 84) |
|---|---|---|---|---|---|---|---|---|---|---|
| Male, n (%) | 32 (54) | 26 (54) | 6 (55) | 20 (54) | 6 (55) | 105 (50) | 94 (52) | 11 (37) | 53 (55) | 41 (49) |
| Age, yrs (mean ± SD) | 55.3 ± 15.3 | 55.9 ± 15.3 | 52.7 ± 15.4 | 54.5 ± 14.2 | 60.9 ± 18.6 | 65.2 ± 12.8 | 65.3 ± 12.7 | 65.0 ± 14.0 | 65.0 ± 13.1 | 65.7 ± 12.2 |
| DFS, mos (mean ± SD) | 80.3 ± 57.5 | 78.2 ± 57.6 | 89.6 ± 58.9 | 71.8 ± 50.1 | 99.7 ± 76.8 | 41.7 ± 45.0 | 39.9 ± 44.4 | 53.0 ± 47.7 | 43.3 ± 47.4 | 35.9 ± 40.5 |
| 8q gain, n (%) | 48 (81) | - | - | - | - | 181 (86) | - | - | - | - |
BAP1 = BRCA1 associated protein 1; BAP1MUT = BAP1 mutated; DFS = disease-free survival; SD = standard deviation; SF3B1 = splicing factor 3b subunit 1; SF3B1MUT = SF3B1 mutated.