TABLE 2.
Characteristics of women in HEIRS Study post‐screening clinical examinations. a
| Characteristic | HFE p.C282Y/p.C282Y (n = 150) | HFE wt/wt (n = 269) | p value |
|---|---|---|---|
| Mean age, y (standard deviation) | 52 ± 13 | 56 ± 14 | 0.0017 |
| Median transferrin saturation, % (range) | 61 (6, 100) | 29 (5, 96) | <0.00001 |
| Median serum ferritin, μg/L (range) | 221 (8, 5060) | 71 (8, 2405) | <0.00001 |
| Median height, cm (range) | 165.1 (144.8, 180.3) | 162.6 (137.2, 182.9) | 0.0298 b |
| Median weight, kg (range) | 74.5 (44.9, 138.5) | 71.7 (43.1, 135.3) | 0.3732 |
a
HEIRS Study, Hemochromatosis and Iron Overload Screening Study; wt/wt, absence of HFE p.C282Y (rs1800562; (OMIM accession *613609; NM_000410.4(HFE):c.845G>A (p.Cys282Tyr)) and p.H63D (rs1799945).
b
Z‐transformed height measures in women with p.C282Y/p.C282Y (mean 0.1432 ± 1.0712) and wt/wt (−0.0798 ± 0.9508) also differed significantly (Student's t‐test (two‐tailed) p = 0.0346), confirming that height of women with p.C282Y/p/C282Y is greater than that of women with wt/wt.