Table 3. Associations Between Polygenic Risk Score for Anorexia Nervosa and Anorexia Nervosa and Sleep Disorders in the Mass General Brigham Biobank (n = 47 082)^a.

Disease description	Phecode	Model 1			Model 2
		No. of cases/No. of controls	OR (95% CI)	P value	No. of cases/No. of controls	OR (95% CI)	P value
Anorexia nervosa	305.21	182/17 106	1.36 (1.14-1.63)	<.001	57/6417	NA	NA
Organic or persistent insomnia	327.41	1343/31 569	1.10 (1.03-1.17)	.005	403/11 266	1.18 (1.05-1.33)	.006
Insomnia	327.4	5748/35 974	1.04 (1.00-1.07)	.04	1637/11 266	1.01 (0.94-1.07)	.87
Restless legs syndrome	327.71	1281/31 507	1.07 (1.00-1.14)	.06	397/11 266	0.99 (0.88-1.11)	.84
Central/nonobstructive sleep apnea	327.31	555/30 781	0.95 (0.86-1.05)	.32	172/11 266	0.83 (0.70-0.99)	.04
Sleep apnea	327.3	4161/34 387	0.99 (0.95-1.03)	.66	1190/11 266	1.02 (0.95-1.10)	.64
Parasomnia	327.5	497/30 723	1.02 (0.92-1.13)	.70	154/11 266	1.01 (0.83-1.21)	.95
Obstructive sleep apnea	327.32	6722/36 948	1.01 (0.97-1.04)	.71	1952/11 266	1.01 (0.96-1.08)	.63
Hypersomnia	327.1	989/31 215	1.01 (0.94-1.09)	.72	314/11 266	1.03 (0.90-1.18)	.65
Sleep disorders	327	3048/33 274	1.01 (0.96-1.05)	.73	898/11 266	1.00 (0.92-1.08)	.99

Abbreviations: NA, not applicable; OR, odds ratio.

^a Effect sizes are per SD increase in the polygenic risk score for anorexia nervosa. Associations were tested using adjusted logistic regression models. Model 1 was adjusted for age, sex, genotyping array, batch, and 10 principal components of ancestry (minimal model). Model 2 was further adjusted for body mass index, employment status, smoking status, exercise, alcohol intake, and education attainment (fully adjusted model). Findings for anorexia nervosa are missing for model 2 due to insufficient number of cases. Significance was considered at the Bonferroni threshold for 9 tested sleep disease outcomes (P < .05 / 9 tests).