Table 1.

Reactome content, version 78 (9/2021) versus 86 (9/2023)

Data type	Release 78	Release 86	Change
Human proteins	10 726	11 148	422
Proteoforms	29 466	30 338	872
Chemicals	1940	2025	85
Reactions	13 890	14 803	913
Human disease proteins	352	354	2
Disease variants	4603	4919	316
Chemical drugs	468	1033	565
Protein drugs	39	86	47
Literature references	34 025	37 156	3131

‘Human proteins’ is the number of human UniProt entries (not counting isoforms) annotated in Reactome. Each may be represented as multiple proteoforms to account for covalent modifications and subcellular locations. ‘Disease proteins’ are ones whose germline or somatic variation gives rise to proteins with altered, pathogenic functions. ‘Disease variants’ is the total number of such variant alleles annotated in Reactome.