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. 2023 Nov 28;52(D1):D239–D244. doi: 10.1093/nar/gkad1083

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Illustration of the key new features in MODOMICS. Top panel: Examples of modifications sites identified in rRNAs using high-resolution cryo-EM and fragment-based MS analysis of 80S ribosomes. The modified ribonucleotides are shown in the context of the Coulomb density map displayed as blue mesh, with modifications indicated by red ellipsoids. Below, the validation by mass spectrometry using enzyme-induced RNA fragment analysis is illustrated. Bottom panel: 2D schemes of ribonucleotide residues imported to MODOMICS: 2′-deoxy-2′-(4-ethyl-1H-1,2,3-triazol-1-yl)adenosine 5′-(dihydrogen phosphate), left; [(6-amino-9H-purin-9-yl)-[5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole]-4′yl]methyl dihydrogen phosphate (ANZ), right. Chemical modifications are highlighted in red.