Table 1.
Examples of residues and their new MODOMICS codes
| Moiety name | Short name | MODOMICS code | Phosphate | Sugar | Base |
|---|---|---|---|---|---|
| 1-methyladenosine | m1A | 2000000001A (old code 1A) | absent | ribose | A modified (natural) |
| N(1)-methyladenosine 5′-monophosphate | pm1A | 2000001551A (old code 1551A) | natural | ribose | A modified (natural) |
| 5-bromo-2′-deoxy-cytidine-5′-monophosphate | CBR | 1000000030C | natural | deoxyribose | C modified (unnatural) |
| 2-amino-9-[2-deoxyribofuranosyl]-9H-purine-5′-monophosphate | 2PR | 1000000005X | natural | deoxyribose | other (unnatural) |
| 5-bromo-uridine-5′-monophosphate | 5BU | 2000000010U | natural | ribose | U modified (unnatural) |
| purine riboside-5′-monophosphate | P5P | 2000000056X | natural | ribose | other (unnatural) |
| isoguanosine-5′-monophosphate | IG | 2000000043A | natural | ribose | A modified (unnatural) |
| uracil arabinose-5′-phosphate | UAR | 3000000069U | natural | unnatural | U (natural) |
| 3′-amino-3′-deoxyadenosine 5′-(dihydrogen phosphate) | 8AN | 3000000015A | natural | unnatural | A (natural) |
| guanosine-5′-thio-monophosphate | GS | 4000000041G | unnatural | deoxyribose | G (natural) |
| adenosine-5′-(dithio)phosphate | ADS | 5000000022A | unnatural | ribose | A (natural) |
| uridine 5′-monothiophosphate | U37 | 5000000065U | unnatural | ribose | U (natural) |
Barcode (first digit) 1 = sugar is d-deoxyribose or its derivative (retains all non-hydrogen atoms of d-deoxyribose) and phosphate is natural (in nucleotides) or absent (in nucleosides); 2 = sugar is d-ribose or its derivative and phosphate is natural or absent; 3 = sugar is unnatural and phosphate is natural or absent. 4 = sugar is d-deoxyribose or its derivative, and phosphate is unnatural; 5 = sugar is d-ribose or its derivative, and phosphate is unnatural; 6 = sugar is unnatural and phosphate is unnatural (such cases are not yet present in MODOMICS).