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. 2023 Nov 13;52(D1):D273–D284. doi: 10.1093/nar/gkad1070

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Identification of Ψ modification sites guided by snoRNAs using sno2Psi. (A) Flowchart depicts the workflow of sno2Psi. (B) the barplot shows that the distribution of known (red) and novel (blue) snoRNA-guided Ψs on different gene biotypes. (C) The screenshot from the ‘Browser’ of the ‘Mechanism’ module shows the SNORA38-guided Ψs and their genomic coordinate on the rRNA and mRNA. (D) The predicted 2D structure of SNORA38 has two stem loops and H/ACA boxes (left); The predicted base-pairings between SNORA38 (black) with 28S rRNA and MRPS21 mRNA (red) (right). Ψs in red indicated the putative Ψ site at 2632th U in 28S rRNA and 394th U in MRPS21 mRNA in human.