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. 2023 Nov 13;52(D1):D273–D284. doi: 10.1093/nar/gkad1070

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Distribution correlation of histone modification and RNA modification. (A) Distribution patterns of H3K36me3 and H3K79me2 modifications around m⁶A sites in RMBase v3.0 in HeLa cell line. (B) Distribution patterns of H3K27me3 and H3K9me3 modifications around m⁵C sites in RMBase v3.0 in HCT116 cell line. Pearson correlation coefficient (CC) and P-value are used to evaluate the significance of the potential correlation between RNA modifications and histone modifications. The m⁶A peaks used for Pearson correlation analysis was downloaded from GEO (GSE76414), while the m⁵C peaks were generated by extending 20 nt upstream and downstream from m⁵C sites that stored in RMBase v3.0.