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. 2023 Nov 22;52(D1):D663–D671. doi: 10.1093/nar/gkad1027

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© The Author(s) 2023. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Genes and pathways distribution across pathDIP database versions. Panel A shows the number of genes annotated with any pathway in each version of pathDIP and for each set (curated, extended using only experimental, and extended using experimental and predicted PPIs). Panel B shows the distribution of the number of pathways per gene across versions and sets. For panel B, only genes present in at least two versions were considered. Panel C shows the number of genes present in each pathway type, for every set. Panels D and E show for each degree interval, with the degree being the number of protein interactions as identified using IID, the number of pathways the proteins are annotated with, for each set. In Panel D, protein degree was calculated using only experimental PPIs, while in Panel E it was calculated using experimental and predicted PPIs. Panel F shows the number of genes annotated with a certain number of pathways in each set, separated by pathway type.