Figure 2.

COSMIC data curation flowchart. Depending on the data source and curation objectives, there are three main curation paths in COSMIC. Somatic variant and Actionability curation always require manual standardisation of metadata to COSMIC nomenclatures. Curation of variant data is performed either in a semi-automated way for the systematic screens or manually for targeted screens. Resources such as the Cancer Gene Census, Hallmarks of Cancer or Resistance Mutations require thorough validation and interpretation of experimental data from several sources. These interpretations form the evidence base for categorisation of biomarkers reported to the users e.g. classification of a gene as tumour suppressor.