Skip to main content
. 2023 Dec 21;14:1295096. doi: 10.3389/fphar.2023.1295096

FIGURE 2.

FIGURE 2

Antihyperalgesic effects of acute oral CM extract administration in female BALB/c mice with paclitaxel-induced thermal hyperalgesia at day 7 post-paclitaxel injection. (A) Reaction latencies to heat were measured in paclitaxel-treated female BALB/c mice compared to vehicle-treated counterparts. (B) Reaction latencies to heat were measured before (0 min) and after (30, 60, 90, 120, and 180 min) oral CM extract (62.5–250 mg/kg) administration. Each bar represents the mean + SEM of values obtained from 9–13 animals per treatment group. *p < 0.05, ***p < 0.001, and ****p < 0.0001 compared to the paclitaxel group post-paclitaxel administration and ####p < 0.0001 compared to the paclitaxel group at baseline (two-way ANOVA followed by Bonferroni’s multiple comparison post hoc tests). (C) Dose–response curve of reaction latencies to heat at 1.5 h after CM (31.25–250 mg/kg) administration. Data are mean + SEM of values obtained from 4–13 animals per treatment group. ****p < 0.0001 compared to the paclitaxel group (one-way ANOVA followed by Dunn’s multiple comparison post hoc tests).