FIGURE 3.

Chronic oral CM extract administration in female BALB/c mice prevents the development of paclitaxel-induced thermal hyperalgesia at day 7 post-paclitaxel injection. (A) CM extract (250 mg/kg) was administered to female BALB/c mice in conjunction with paclitaxel injection for 5 days. Reaction latencies to heat were measured before and after oral CM administration. Each bar represents the mean + SEM of values obtained from five animals. (B) CM extract (250 mg/kg) administered to female BALB/c mice for 10 days (5 days before paclitaxel injection and 5 days during paclitaxel injection). Reaction latencies to heat were measured before and after oral CM administration. Each bar represents the mean + SEM of values obtained from 8–13 animals per treatment group. *p < 0.05 and ****p < 0.0001 compared to the paclitaxel group post-paclitaxel (two-way ANOVA followed by Bonferroni’s multiple comparison post hoc tests).