FIGURE 4.

Chronic oral CM extract administration in female BALB/c mice prevents the development of paclitaxel-induced mechanical allodynia at day 7 post-paclitaxel injection. (A) Withdrawal thresholds to the mechanical stimulus were measured in paclitaxel-treated female BALB/c mice compared to vehicle-treated counterparts. (B) CM extract (250 mg/kg) administered to female BALB/c mice for 10 days (5 days before paclitaxel injection and 5 days during paclitaxel injection). Withdrawal thresholds to the mechanical stimulus were measured before and after oral CM administration. Each bar represents the mean + SEM of values obtained from 9–10 animals per treatment group. **p < 0.01, ***p < 0.001, and ****p < 0.0001 compared to the paclitaxel group post-paclitaxel and ####p < 0.0001 compared to the paclitaxel group at baseline (two-way ANOVA followed by Bonferroni’s multiple comparison post hoc tests or Dunn’s multiple comparison post hoc tests).