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. 2023 Dec 21;14:1295096. doi: 10.3389/fphar.2023.1295096

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Copyright © 2023 Al-Romaiyan, Barakat, Jose and Masocha.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Oral CM extract ameliorates capsaicin-induced nociception in female BALB/c mice. CM extract (250 mg/kg) or its vehicle was administered orally to female BALB/c mice 1 h and 30 min before injecting capsaicin (5 µg/20 µL) into the dorsal surface of the right hind of the mice. Nociceptive behaviors in response to capsaicin such as the number (A) and the amount of time (B) spent on licking, biting, flinching, or lifting the injected paw were measured over 5 min. Each bar represents the mean + SEM of values obtained from eight animals per treatment group. **p < 0.01 compared to the vehicle-treated group (unpaired Student’s t-test).