Table 1.

Sensitivity analysis for immune markers that showed significant correlations with ALS.

Immune marker	Cochran’s Q		MR Eggr		MR.PRESSO
	Q	p	Intercept	p	Global test p	Distortion test p	p (outlier-corrected)
Leukocyte count	736	<0.001	0.003	0.024	<0.001†	na⁑	na⁑
Lymphocyte count (ebi-a-GCST004627)	345.139	<0.001	0.005	0.023	<0.001†	na⁑	na⁑
Lymphocyte count (ieu-b-32)	1407.652	<0.001	<−0.001	0.849	<0.001†	0.949	<0.001
Lymphocyte count (ukb-d-30120_irnt)	685.914	<0.001	0.003	0.079	<0.001†	0.904	<0.001
CD3 on effector memory CD4+ T cell	3.752	0.153	0.034	0.461	na‡	–	–
CD3 on HLA DR+ CD4+ T cell	0.574	0.75	0.017	0.588	na‡	–	–
CD3 on effector memory CD8+ T cell	1.044	0.593	−0.004	0.933	na‡	–	–
CD3 on terminally differentiated CD8+ T cell	0.895	0.344	na‡	na‡	na‡	–	–
CD3 on CD28− CD8+ T cell	0.132	0.716	na‡	na‡	na‡	–	–
α-2-MRAP (prot-a-1781)	16.436	0.423	−0.006	0.614	0.486	–	–
α-2-MRAP (prot-c-3640_14_3)	6.323	0.707	−0.024	0.27	0.731	–	–
C4b	5.974	0.113	0.014	0.831	0.236	–	–
Interleukin-21	6.068	0.733	−0.027	0.192	0.736	–	–

^†The MR PRESSO outlier test was performed due to the existence of horizontal pleiotropy.

^‡The test was not conducted due to not enough instrumental variables.

^⁑No significant outliers in MR.PRESSO Distortion test.