Table 4.
γδ T cell Markers (human).
| Type of T cell | Annotation tool | Feature set |
|---|---|---|
| γδ T cell | scGate | TRDC, TRGC1, TRGC2, and TRDV1 |
| CellTypist^ | TRDC, TRGC1, CCL5 | |
| Literature (29)* | TRDV1, TRGV3, TRDV2 | |
| Innate (CD8 panel) | scGate | TRDC, TRGC1, TRGC2, TRDV1, TRDV2 |
| Activated Vδ1+ | Literature (30) | NKp44 (NCR2), NKp46 (NCR1), and NKp30 (NCR3) |
| Activated | Literature (31) | NKp30 (NCR3), CCL3, CCL4, and CCL5 |
| Vδ2γ9+ | Literature (30) | TRGV9, TRDV2, and NKG2D |
| Activated Vδ2γ9+ | Literature (30) | TRGV9, TRDV2, NKG2D, TNFα (TNF), CD16, and CCL4/CCL5 |
| T17 | Literature (30, 32) | TRDC, TRGC1, IL-17, and IFNγ |
| CTL | Literature (30) | NKG2D, PFR1, GZMB, GNLY and possibly express: CD95L TRAIL, CD27 |
| Regulatory | Literature (32) | FOXP3 |
| Naive | Literature (30) | IFNγ in presence of IL-2/IL-15 |
| Data2Talk& | ND | |
| Tcm | Data2Talk& | ND |
| Tem | Data2Talk& | ND |
| Eff | Data2Talk& | ND |
| Exhausted | Data2Talk& | ND |
| MAIT | Data2Talk& | ND |
| Cycling γδ T cells | CellTypist | MKI67, TOP2A, and TRDC |
| CRTAM+ γδ T cells | CellTypist | ITGAD, TRDC, and IKZF2 |
CTL, Cytotoxic T cells; Tcm, central memory; Tem, effector memory; CRTAM, Cytotoxic And Regulatory T Cell Molecule; Eff, effector; Trm, Tissue resident memory; MAIT, mucosal invariant T cells.
&Bioturing can predict cell types based on 80,574,317 cells https://talk2data.bioturing.com/predict
^Curated markers from CellTypist (V1 list of markers).
*Based on Figure 1 top associated markers from a single-cell study.
ND, Not disclosed.