Table 2.

Descriptions of Evidence to Decision (EtD) factors that determine the direction and strength of a recommendation in WHO guidelines [45] (page 124)

EtD factor	How the factor influences the direction and strength of a recommendation
Values and preferences	This describes the relative importance assigned to health outcomes by those affected by them; how such importance varies within and across populations; and whether this importance or variability is surrounded by uncertainty. The less uncertainty or variability there is about the values and preferences of people experiencing the critical or important outcomes, the greater the likelihood of a strong recommendation.
Resource implications	This pertains to how resource-intense an intervention is, whether it is cost–effective and whether it offers any incremental benefit. The more advantageous or clearly disadvantageous the resource implications are, the greater the likelihood of a strong recommendation either for or against the intervention.
Equity and human rights	The greater the likelihood that the intervention will reduce inequities, improve equity, or contribute to the realization of one or several human rights as defined under the international legal framework, the greater the likelihood of a strong recommendation.
Acceptability	The greater the acceptability of an option to all or most stakeholders, the greater the likelihood of a strong recommendation.
Feasibility	The greater the feasibility of an option from the standpoint of all or most stakeholders, the greater the likelihood of a strong recommendation. Feasibility overlaps with values and preferences, resource considerations, existing infrastructures, equity, cultural norms, legal frameworks, and many other considerations.