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Complement-targeted therapeutics in lung disease
| Name | Target | Type | Indication | Company | References |
|---|---|---|---|---|---|
| Eculizumab (Soliris®) | C5 | mAb | COVID-19 | Alexion | [157–159] |
| Vilobelimab | C5a | mAb | COVID-19, cutaneous squamous cell carcinoma | InflaRx | [156, 163, 164] |
| AMY-101 | C3 | compstatin peptide | COVID-19 | Amyndas Pharmaceuticals | [160–162] |
| Narsoplimab | MASP-2 | mAb | COVID-19 | Omeros | [165] |
| Avdoralimab | C5aR1 | mAb | Solid tumours, non-small cell lung cancer | Innate Pharma | [142] |
mAb: monoclonal
