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. 2024 Jan 5;25(1):3. doi: 10.1186/s10194-023-01707-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — NF-κB inhibition attenuates NTG-induced pain hypersensitivity. PDTC effectively prevented the decrease in both basal and acute mechanical withdrawal thresholds of the hind paw (a, b) and periorbital area (c, d) and extended the heat withdrawal latency (e, f) . Acute hypersensitivity reactions were detected 2 hours after each NTG treatment. Values are the mean ± SEM; n = 10; two-way ANOVA and Tukey's post hoc tests; ***p < 0.001 vs. the VEH group; ^###p < 0.001 vs. the NTG group; ^&&&p < 0.001, the NTG-PDTC group vs. the VEH-PDTC group.