Table 8.

Circuits preferentially processing paranoid and depressive scale [regions activated (“þ”)/deactivated (“−”) by the condition]

Brain region	Brodmann areas	Activated (+) deactivated (-)
Common circuit for all conditions
Right inferior frontal gyrus	13, 45, 47	+
Right superior temporal gyrus	21, 22, 38	+
Right insula	13, 22	+
Left inferior parietal lobule	40	-
Left inferior frontal gyrus	44, 45, 46	-
Left middle frontal gyrus	8, 10, 46	-
Paracentral lobule	5, 6	-
Shared circuit, between conditions DS and DP
Left inferior parietal lobule	40
Right paracentral lobule	5, 6
Right medial frontal gyrus	6
Left middle frontal gyrus	8, 9, 10, 11, 47
Left superior frontal gyrus	6, 8, 9, 10
Shared between DP and DN
Right sub-gyral	1	+
Distinct (appear in one component), condition DS
Right cuneus	17, 18, 19, 23, 30	+
Right lingual gyrus	17, 18, 19	+
Right middle occipital gyrus	18, 19	+
Right cuneus	17, 18, 19
Right middle occipital gyrus	18, 19
Left lingual gyrus	18, 19, 30	+
Left culmen		+
Left fusiform gyrus	19, 37	+
Left parahippocampal gyrus	19, 30, 36, 37	+
Left cuneus	18, 23, 30	+
Left sub-gyral	37	+
Distinct (appear in one component), condition DP
Left postcentral gyrus	1, 2, 3, 4, 40	+
Left superior frontal gyrus	6, 8, 9, 10	+
Left medial frontal gyrus	6, 8, 9, 32	+

¹Subcortical area.

Distinct neutral items (DN)-no distinct circuit, specific for DN is reported, which supports the assumption, that the items from that scale are diagnostically neutral. DP: Diagnostic paranoid; DS: Depression specific; DN: Neutral items.