Table 5.
Univariable and multivariable analysis for overall survival (mutations sub-analysis).
| Variable | Univariable | Multivariable | ||||
|---|---|---|---|---|---|---|
| HR | p Value | HR | p Value | CI 95% | CI 95% | |
| Age (continuous) | 1.077 | <0.001 | 1.102 | <0.001 | 1.053 | 1.153 |
| Sex (male versus female [ref]) | 1.869 | 0.036 | 2.419 | 0.020 | 1.148 | 5.096 |
| Transfusion dependency (yes versus not [ref]) | 2.791 | 0.012 | 3.490 | 0.007 | 1.417 | 8.599 |
| IPSS (int-1 versus low [ref]) | 2.297 | 0.010 | 2.827 | 0.010 | 1.279 | 6.251 |
| Hemoglobin (continuous) | 0.786 | 0.055 | ||||
| Hemoglobin (<8 versus ⩾8 g/dl [ref]) | 1.523 | 0.259 | ||||
| Leukocytes (continuous) | 1.023 | 0.225 | ||||
| Platelets (continuous) | 0.999 | 0.273 | ||||
| Bone marrow blasts (continuous) | 1.257 | 0.004 | 1.028 | 0.778 | 0.848 | 1.247 |
| Serum EPO (continuous) | 0.999 | 0.552 | ||||
| Serum EPO (⩾100 versus <100 U/l [ref]) | 0.846 | 0.631 | ||||
| Serum EPO (⩾200 versus <200 U/l [ref]) | 0.873 | 0.779 | ||||
| Ferritin (⩾500 versus <500 ng/ml [ref]) | 0.917 | 0.797 | ||||
| Cytogenetics (abnormal versus normal [ref]) | 1.969 | 0.045 | 1.371 | 0.421 | 0.635 | 2.956 |
| WHO 2008 classification (<5% blasts versus 5q− [ref]) | 0.552 | 0.276 | ||||
| ⩾5% blasts and CMML versus <5% blasts [ref] | 5.632 | 0.012 | ||||
| Mutated genes (⩾3 versus <3 [ref]) | 1.247 | 0.028 | 2.803 | 0.015 | 1.223 | 6.425 |
| SRSF2 (mutated versus wt [ref]) | 3.914 | 0.001 | 2.285 | 0.157 | 0.727 | 7.182 |
| STAG2 (mutated versus wt [ref])* | 11.665 | <0.001 | ||||
| GNAS (mutated versus wt [ref])* | 6.550 | 0.003 | ||||
CMML, chronic myelomonocytic leukemia; EPO, erythropoietin; IPSS, International Prognostic Scoring System; IPSS-R, IPSS Revised; WHO, World Health Organization.
*
STAG2 and GNAS were not included in the multivariable analysis because of a disproportionally high CI.