Table 1.
Comparisons Between the High and Low NPR Groups.
| High NPR (n = 69) | Low NPR (n = 178) | P-value | |
|---|---|---|---|
| Age (years), mean ± SD | 70.68 ± 9.88 | 66.19 ± 13.10 | .004 |
| Male, n (%) | 47 (68.1%) | 109 (61.2%) | .315 |
| Hypertension, n (%) | 52 (75.4%) | 119 (66.9%) | .194 |
| Diabetes, n (%) | 29 (42.0%) | 58 (32.6%) | .163 |
| Uric acid (μmol/L), median (IQR) | 368 (307-428.5) | 353 (297.75-409) | .173 |
| Platelet count (10^9/L), median (IQR) | 145.5 (123-190.25) | 204.5 (165.75-238.3) | ＜.001 |
| Neutrophil (10^9/L), median (IQR) | 6.9 (5.07-8.55) | 4.36 (3.5-5.63) | ＜.001 |
| Hs-CRP (10^9/L), median (IQR) | 2.1 (0.81-4.48) | 1.6 (0.76-3.26) | .328 |
| Lymphocyte, median (IQR) | 1.43 (1.0-2.23) | 1.84 (1.36-2.49) | .008 |
| Baseline NIHSS, median (IQR) | 5 (3-9) | 4 (2-7.25) | .04 |
| Atrial fibrillation, n (%) | 15 (21.7%) | 33 (18.5%) | .59 |
| Smoking, n (%) | 17 (24.6%) | 35 (19.7%) | .39 |
| Cholesterol, median (IQR) | 4.3 (3.49-5.13) | 4.25 (3.42-5.02) | .64 |
| Triglyceride, median (IQR) | 1.21 (0.87-1.68) | 1.35 (0.9-1.82) | .41 |
| Low-density lipoprotein, median (IQR) | 2.25 (1.86-3.45) | 2.32 (1.84-3.11) | .62 |
| Infarct area (anterior vs posterior circulation), n (%) | 64 (92.8%) | 173 (97.2%) | .11 |
| Vascular stenosis | .008 | ||
| Intracranial vascular stenosis, n (%) | 23 (33.3%) | 50 (28.1%) | |
| Extracranial vascular stenosis, n (%) | 8 (11.6%) | 43 (24.2%) | |
| Intracranial and extracranial vascular stenosis, n (%) | 33 (47.8%) | 17 (9.6%) | |
| Past drug use | .313 | ||
| Aspirin, n (%) | 10 (14.5%) | 19 (10.7%) | |
| Anticoagulant, n (%) | 7 (10.1%) | 9 (5.1%) | |
| clopidogrel, n (%) | 1 (1.5%) | 6 (3.4%) | |
| Heart failure, n (%) | 2 (2.9%) | 3 (1.7%) | .544 |
| Coronary heart disease, n (%) | 6 (8.7%) | 12 (6.7%) | .596 |
| Cancer, n (%) | 1 (1.4%) | 5 (2.8%) | .533 |
| Connective tissue disease, n (%) | 0 (0%) | 1 (0.56%) | .533 |
| Coagulation factor function, n (%) | 69 (100%) | 178 (100%) | 1 |
| sICH, n (%) | 10 (14.5%) | 3 (1.7%) | ＜.001 |
| HT, n (%) | 21 (30.4%) | 25 (16.3%) | .003 |
Abbreviations: NIHSS, National Institutes of Health Stroke Scale; IQR, interquartile range; SD, standard deviation; hs-CRP, Hypersensitive C-reactive protein; HT, hemorrhagic transformation; sICH, symptomatic intracranial hemorrhage; NPR, neutrophil-platelet ratio.