TABLE 4.
Circulating insulin levels before and after sleeve gastrectomy.
| Non‐diabetes n = 8 | Within group effect of time | Diabetes n = 8 | Within group effect of time | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 6W | 6M | Baseline | 6W | 6M | |||
| Fasting insulin (μU/mL) | 10.7 ± 5.3 | 6.2 ± 4* | 5.0 ± 2.5* | F = 7.5, p = 0.01 | 17.4 ± 11.2 | 9.2 ± 5.1 | 6.7 ± 3.8* | F = 5.7, p = 0.02 |
| 30‐min insulin (μU/mL) | 105.3 ± 95 | 109.1 ± 149 | 122.2 ± 92.8 | NS | 34.1 ± 20† | 64.5 ± 42.0* | 79.8 ± 44.2* | F = 5.8, p = 0.01 |
| 1‐h insulin (μU/mL) | 82.3 ± 35.1 | 115.2 ± 166.8 | 96.4 ± 107 | NS | 38.7 ± 27.2† | 83.5 ± 65.8 | 80.3 ± 29.3 | NS |
| 2‐h insulin (μU/mL) | 80.03 ± 53.4 | 90.7 ± 208 | 12 ± 7.4 | NS | 36.6 ± 33.1† | 44.1 ± 33.7 | 18.9 ± 14.2 | NS |
| Insulin AUC (uU h/mL) | 161 ± 71.4 | 133 ± 123 | 140 ± 95 | NS | 74 ± 37.7 | 129 ± 82.0 | 112 ± 39.0 | NS |
| Matsuda index | 3.8 ± 1.8 | 6.1 ± 3.0 | 6.4 ± 2.0 | NS | 2.7 ± 2.0 | 3.7 ± 2.2 | 4.6 ± 2.1** | F = 3.9, p = 0.046 |
| HOMA‐IR | 2.5 ± 1.4 | 1.4 ± 0.8* | 1.0 ± 0.5* | F = 7.5, p = 0.01 | 8.4 ± 6.5†† | 2.8 ± 2.0*,† | 1.7 ± 1.0* | F = 10.2, p = 0.01 |
| Disposition index | 4.4 ± 3.6 | 8.3 ± 4.7 | 11.7 ± 10.3* | F = 5.2, p = 0.05 | 0.9 ± 1.5† | 1.7 ± 2.2††† | 3.5 ± 2.3*,† | F = 5.2, p = 0.02 |
Abbreviation: NS, not significant.
Post‐hoc Bonferroni comparisons: *p < 0.05, compared to baseline data, within group comparison. **p < 0.01, compared to baseline, within group comparison. ***p < 0.001, compared to baseline, within group comparison.
Group Comparisons: † p < 0.05, group comparison at the same time point. †† p < 0.01, group comparison at the same time point. ††† p < 0.001, group comparison at the same time point.