Table 5:
Hazard ratio of all-cause mortality associated with a double increase in baseline serum-free kynurenine level (mg/L).
| Free kynurenine (mg/L) | |
|---|---|
| Unadjusted HR [95% CI]—P-value | 1.7 [1.5, 1.9]–<0.001 |
| Adjusted HR a [95% CI]—P-value | 1.22 [1.02, 1.5]–0.03 |
| Adjusted HR b [95% CI]—P-value | 1.12 [0.9, 1.4]–0.3 |
| Adjusted HR c [95% CI]—P-value | 1.18 [0.9, 1.4]–0.07 |
a
Model adjusted for age at baseline, sex, high-sensitivity C-reactive protein, serum albumin, urea, diabetes, dyslipidemia, body mass index, smoking status, baseline estimated glomerular filtration rate, urine albumin- or protein-to-creatinine ratio, systolic blood pressure, prescriptions of diuretics, antihypertensive drugs, lipid-lowering drugs, and antidiabetic drugs.
b
1 + serum-free tryptophan.
c
1 + serum-free indoxyl sulfate, indole-3-acetic acid and p-cresyl sulfate.